PReS-FINAL-2058: Lipid peroxides, lipophuscin, sulfhydryl groups and TOS in children with JIA

Introduction The etiology of most joints’ inflammations is unknown. Arthritis in children can have a diversified course. Various parameters useful in diagnosis and treatment of different forms of inflammations of the joints are being researched. Reactive oxygen species in large concentrations are toxic and cause, among others, the phenomenon of polyunsaturated fatty acids lipid peroxidation, which results in the formation of aldehyde compounds. Non enzymatic antioxidants include: lipid peroxides (LHP = LOOH), lipophuscin (LF). An important part of non enzymatic antioxidative defense are sulfhydryl groups-SH. Total oxidative status (TOS) is used as an indicator of the overall oxidative potential of cells.